| Player | Club | I. D. Year | Goals |
|---|---|---|---|
  Junior Yabwana | Olimpico | 2021-2022 | 27 |
  Isidro Chavarria Moreno | Michoacan | 2021-2022 | 26 |
  Niall Torricelli | Inter | 2021-2022 | 22 |
  Clark O’neil | Olimpico | 2021-2022 | 21 |
  Tariq Aldaly | Real El Llano | - | 17 |
  Joseph Nazar Arteen | Olimpico | 2021-2022 | 16 |
 Triston Austin | Inter | - | 14 |
 Luis De Anda | Papayo | - | 13 |
 Widner Saint Cyr | Alebrijes | 2021-2022 | 12 |
  Nasir Abdalla | MB United | 2021-2022 | 12 |
